2145091-51-4

2145091-51-4 structure

2145091-51-4 structure

Name: Pacmilimab
Chemical Name: Pacmilimab
CAS Number: 2145091-51-4
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2023-04-13 19:00:21
Modify Date: 2024-04-06 11:15:58
Pacmilimab (CX-072) is a potent PD-L1 inhibitor. Pacmilimab shows antitumor activity[1].

Name	Pacmilimab

Description	Pacmilimab (CX-072) is a potent PD-L1 inhibitor. Pacmilimab shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
In Vivo	Pacmilimab 在携带 MC38 肿瘤的小鼠中诱导的抗肿瘤反应与相同剂量的亲本抗体相当[1]。 Pacmilimab 在小鼠 PD-L1 表达肿瘤中积累，外周非癌性淋巴组织摄取最少，这与在非肿瘤 PD-L1 表达组织中摄取有限和自身免疫保护相一致[1] .
References	[1]. Naing A, et al. CX-072 (pacmilimab), a Probody ® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study. J Immunother Cancer. 2021 Jul;9(7):e002447.

No Any Chemical & Physical Properties