2348469-43-0

2348469-43-0 structure

Name: Geptanolimab
Chemical Name: Geptanolimab
CAS Number: 2348469-43-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2023-02-19 06:58:01
Modify Date: 2024-01-13 17:46:20
Geptanolimab (CBT-501) is a humanized IgG4k monoclonal antibody against programmed death-1 (PD-1). Siplizumab inhibits the binding of PD-L1/L2 to PD-1 through a competitive action. Siplizumab can be used in research of cancer[1].

Name	Geptanolimab

Description	Geptanolimab (CBT-501) is a humanized IgG4k monoclonal antibody against programmed death-1 (PD-1). Siplizumab inhibits the binding of PD-L1/L2 to PD-1 through a competitive action. Siplizumab can be used in research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
In Vitro	Geptanolimab (CBT-501) 与人 (KD=505 pM) 和猕猴 (KD=7.2 nM) 的 PD-1 具有高度特异性结合[ 1]。 Geptanolimab 增强混合淋巴细胞反应 (MLR) 中的人 T 细胞活化，增加 IL-2 和 INF-γ 的释放[1]。
In Vivo	Geptanolimab (CBT-501; ip; 每两周一次, 持续6周; MC38同系肿瘤模型小鼠) 具有抗肿瘤活性，抑瘤率达到 83%[1]。
References	[1]. Qing Z, et, al. Activity of CBT-501, a novel humanized anti-PD-1 antibody, in a humanized genetically engineered mouse model of colon carcinoma. Journal of Clinical Oncology. 2017;35 (7_suppl):108-108.

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