1310460-86-6

1310460-86-6 structure

Name: Modotuximab
Chemical Name: Modotuximab
CAS Number: 1310460-86-6
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2023-03-14 12:37:00
Modify Date: 2024-04-06 23:07:17
Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo[1].

Name	Modotuximab

Description	Modotuximab (Anti-Human EGFR Recombinant Antibody) is an IgG1κ-type chimeric antibody targeting human EGFR protein. Modotuximab contains a portion of Futuximab that binds to two independent, non-overlapping epitopes on EGFR. Modotuximab promotes cross-linking of EGFR on the cell surface and promotes EGFR cellular internalization and degradation. Modotuximab has antitumor activity in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. KeirST, et al. Sym004-induced EGFRelimination is associated with profound anti-tumor activity in EGFRvIIIpatient-derived glioblastoma models. J Neurooncol. 2018 Jul;138(3):489-498. [2]. Modotuximab. IMGT Database.

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