917121-25-6
917121-25-6 structure
- Name: Topsalysin
- Chemical Name: Topsalysin
- CAS Number: 917121-25-6
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-25 16:38:59
- Modify Date: 2025-08-25 11:58:44
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Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle[1].
| Name | Topsalysin |
|---|
| Description | Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle[1]. |
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| Related Catalog | |
| In Vitro | Topsalysin (19 pM-10 nM; 48 小时) 对 LNCaP, PC3, DU145 和 TSU 细胞显示前列腺特异性抗原 (PSA) 依赖性毒性[1]。 |
| In Vivo | Topsalysin (肿瘤内注射; 1-10μg /鼠标; 单次剂量) 抑制小鼠的肿瘤生长[1]。 Topsalysin (0.35、4.1、25.8 μg/kg, 25 μL; 腹腔注射; 单剂量) 可杀死食蟹猴前列腺注射部位高达 50% 的细胞[1]。 Animal Model: Nude mice (6-week-old) subcutaneously bearing tumors[1] Dosage: 0, 1, 5, and 10 μg Administration: Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days Result: Showed prostate-specific antigen (PSA)-dependent toxicity in mice. |
| References |
| No Any Chemical & Physical Properties |