945373-85-3
945373-85-3 structure
- Name: Properdistatin
- Chemical Name: Properdistatin
- CAS Number: 945373-85-3
- Molecular Formula: C89H149N33O27S2
- Molecular Weight: 2177.47
- Catalog: Research Areas Cancer
- Create Date: 2023-03-06 18:06:27
- Modify Date: 2024-04-06 20:32:08
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Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma[1].
| Name | Properdistatin |
|---|
| Description | Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Properdistatin (80 mg/kg; 腹腔注射; 每日一次, 持续 4 天) 抑制小鼠黑色素瘤异种移植模型的血管生成并改善血管功能[1]。 Animal Model: Adult female BALB/c nu/nu mice (R-18, A-07, and D-12 human melanoma cells)[1] Dosage: 80 mg/kg Administration: I.p.; daily for 4 days Result: Inhibited angiogenesis in human melanoma xenografts with low TSP-1 expression, selectively removed small-diameter capillaries, but did not change the morphology of tumor arterioles or tumor venules, and reduced blood supply times and increased plasma velocities. |
| References |
| Molecular Formula | C89H149N33O27S2 |
|---|---|
| Molecular Weight | 2177.47 |