1965342-40-8

1965342-40-8 structure
1965342-40-8 structure
  • Name: ODN 105870
  • Chemical Name: ODN 105870
  • CAS Number: 1965342-40-8
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
  • Create Date: 2023-02-16 17:40:10
  • Modify Date: 2024-04-02 23:08:53
  • ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].

Name ODN 105870
Description ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research[1].
Related Catalog
In Vitro ODN 105870 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1]. In case of Imiquimod-stimulated B cells, ODN 105870 (10 μM) reduces the ATP content to the pretreatment level[1].
References

[1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.  

No Any Chemical & Physical Properties