1510653-27-6
1510653-27-6 structure
- Name: G0-C14
- Chemical Name: G0-C14
- CAS Number: 1510653-27-6
- Molecular Formula: C106H216N10O10
- Molecular Weight: 1790.91
- Catalog: Research Areas Cancer
- Create Date: 2023-03-09 11:37:27
- Modify Date: 2025-08-25 11:03:43
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G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for drug and vaccine delivery[1][2].
| Name | G0-C14 |
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| Description | G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for drug and vaccine delivery[1][2]. |
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| Related Catalog | |
| In Vitro | G0-C14 表现出强烈的 mRNA 和 pDNA 包封特性，包封率在 95% 以上[1]。 NPs的制备[1]:1.将 PolyHCPT 和 DSPE-PEG3K 溶解在 DMF 中，形成浓度为 5 mg/mL 的均匀溶液。2.制备 1 nmol siRNA (0.1 nmol/µL 水溶液) 和 G0-C14 (5 mg/mL DMF) 的不同 N/P 摩尔比的混合物。将其与 PolyHCPT 和 DSPE-PEG3K 溶液混合。3.在剧烈搅拌 (1000 转/分钟) 下，将混合物滴入 5 毫升去离子水中。4.将形成的 NP 分散物转移到超滤装置。5.在室温下离心 (2800 rpm×8 min) 去除有机溶剂和游离化合物。 |
| References |
| Molecular Formula | C106H216N10O10 |
|---|---|
| Molecular Weight | 1790.91 |