2467411-25-0

2467411-25-0 structure

Name: Fiztasovimab
Chemical Name: Fiztasovimab
CAS Number: 2467411-25-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection CMV
Create Date: 2023-01-26 13:09:49
Modify Date: 2024-04-10 18:27:35
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV[1].

Name	Fiztasovimab

Description	Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> CMV
In Vitro	Fiztasovimab is isolated from Epstein-Barr virus-transformed peripheral B cells of a healthy donor[1]. Fiztasovimab has a broadly neutralizing activity against 4 laboratory strains (AD169, Towne, Davis, Merlin) and 42 Japanese clinical isolates, which included GCV-resistant isolates[1]. Fiztasovimab shows anti-hMCV activities in MRC-5 human embryonic fibroblast cells and human adult retinal pigment epithelial cells with IC50s of 13-105 ng/mL and IC90s of 0.208-1.026 μg/mL[1]. Fiztasovimab also inhibits cell-to-cell infection by hCMV isolates in adult retinal pigment epithelial cells with IC90s of 13-19 μg/mL[1].
References	[1]. Furihata K, et al. Pharmacokinetics, Safety, and Tolerability of NPC-21, an Anti-Cytomegalovirus Monoclonal Antibody, in Healthy Japanese and White Adult Men: A Randomized, Placebo-Controlled, First-in-Human Phase 1 Study. Clin Pharmacol Drug Dev. 2022 Jun;11(6):707-716.

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