2760611-38-7
2760611-38-7 structure
- Name: CYP4Z1-IN-1
- Chemical Name: CYP4Z1-IN-1
- CAS Number: 2760611-38-7
- Molecular Formula: C13H18N2O3
- Molecular Weight: 250.29
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2023-01-30 09:38:52
- Modify Date: 2024-08-09 11:12:02
-
CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1].
| Name | CYP4Z1-IN-1 |
|---|
| Description | CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1]. |
|---|---|
| Related Catalog | |
| Target |
CYP4Z1:41.8 ± 1.4 nM (IC50) CYP4F11:291.3 ± 46 nM (IC50) CYP4F12:1598.3 ± 5 nM (IC50) CYP2D6:>10 000 nM (IC50) CYP2C9:>10 000 nM (IC50) CYP3A4:>10 000 nM (IC50) |
| In Vitro | CYP4Z1-IN-1 (compound 7c) 显示出对乳腺 CSC (癌症干细胞)的抗增殖活性，IC50 为 483 ± 2.5 nM[1] 。 CYP4Z1-IN-1 (0.8-51.2 μM, 24 h) 抑制乳腺癌细胞中干细胞标记物 (P-gp, Oct3/4, Nanog, ALDH1A1, 和 Sox2) 的表达[1]。 CYP4Z1-IN-1 (0.8-51.2 μM, 24-48 h) 可减弱乳腺癌细胞的迁移和侵袭能力[1]。 Western Blot Analysis[1] Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 0.8 μM, 3.2 μM, 12.8 μM, 51.2 μM Incubation Time: 24 h Result: Significantly suppressed the protein expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in MCF-7 cells in a concentration-dependent manner. |
| In Vivo | CYP4Z1-IN-1 (compound 7c) (2000 mg/kg，口服，连续 7 天)对小鼠没有明显的毒性和体重减轻[1]。 CYP4Z1-IN-1 (12.8 μM, 72 h处理MCF-7 and MDA-MB-231 cells，然后细胞皮下植入小鼠腹股沟乳腺) 可阻断乳腺癌细胞的肿瘤启动能力[1]。 Animal Model: Mice[1] Dosage: 2000 mg/kg Administration: orally, for 7 days Result: Showed that compound 7c was rather safe; no evident toxicity and body weight loss were observed. Animal Model: BALB/c-nude mice (3-4 week old, female)[1] Dosage: 12.8 μM Administration: MCF-7 and MDA-MB-231 cells were pre-treated with 7c (12.8 μM) for 72 h and were then implanted in the inguinal mammary gland of mice subcutaneously Result: Blocked the tumor-initiating ability of breast cancer cells. |
| References |
| Molecular Formula | C13H18N2O3 |
|---|---|
| Molecular Weight | 250.29 |