2685779-55-7

2685779-55-7 structure

2685779-55-7 structure

Name: CYP1B1-IN-4
Chemical Name: CYP1B1-IN-4
CAS Number: 2685779-55-7
Molecular Formula: C₁₈H₁₄N₂O₂S
Molecular Weight: 322.38
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2023-02-06 16:11:37
Modify Date: 2024-01-20 20:23:15
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].

Name	CYP1B1-IN-4

Description	CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	CYP1B1:0.2 nM (IC50) CYP1A1:3.98 μM (IC50)
In Vitro	CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低[1]。 CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC50 为 3.82 μM[1]。 Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性[1]。
References	[1]. Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15.

Molecular Formula	C₁₈H₁₄N₂O₂S
Molecular Weight	322.38