2260568-31-6

2260568-31-6 structure
2260568-31-6 structure
  • Name: Bentracimab
  • Chemical Name: Bentracimab
  • CAS Number: 2260568-31-6
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2023-02-19 18:25:42
  • Modify Date: 2024-04-06 12:37:35
  • Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor[1].

Name Bentracimab
Description Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor[1].
Related Catalog
In Vivo Bentracimab 结合的 Ticagrelor 主要与 Bentracimab 一起在肾脏中被消除,而不是再循环到血浆中[2]。
References

[1]. Kathman SJ, et, al. Population pharmacokinetic-pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers. CPT Pharmacometrics Syst Pharmacol. 2022 Jan;11(1):68-81.  

[2]. Almquist J, et, al. Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling. CPT Pharmacometrics Syst Pharmacol. 2016 Jun;5(6):313-23.  

No Any Chemical & Physical Properties
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