2719691-01-5

2719691-01-5 structure

2719691-01-5 structure

Name: AZ-5104-d2
Chemical Name: AZ-5104-d2
CAS Number: 2719691-01-5
Molecular Formula: C₂₇H₂₉D₂N₇O₂
Molecular Weight: 487.59
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-03-05 20:24:51
Modify Date: 2024-04-05 18:49:44
AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].

Name	AZ-5104-d2

Description	AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61.

Molecular Formula	C₂₇H₂₉D₂N₇O₂
Molecular Weight	487.59