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267227-08-7

267227-08-7 structure

267227-08-7 structure

Name: Apolizumab
Chemical Name: Apolizumab
CAS Number: 267227-08-7
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-03-11 13:31:25
Modify Date: 2024-04-09 12:37:11
Apolizumab (Hu1D10) is a humanized monoclonal anti-Human leukocyte antigen-DR beta-chain antibody. Apolizumab can mediate apoptosis of chronic lymphocytic leukemia (CLL) cells in vitro[1][2].

Name	Apolizumab

Description	Apolizumab (Hu1D10) is a humanized monoclonal anti-Human leukocyte antigen-DR beta-chain antibody. Apolizumab can mediate apoptosis of chronic lymphocytic leukemia (CLL) cells in vitro[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
In Vitro	Apolizumab can induce ADCC and CMC based on expression of target antigen[2]. Apolizumab alter cell membrane polarization and permeability but may not induce apoptosis directly[2].
References	[1]. Thomas S Lin, et al. A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia. Leuk Lymphoma. 2009 Dec;50(12):1958-63. [2]. Matthew L. Hill DO, et al. In Vitro Activity of the Humanized Anti-HLA-DR Antibodies KRN848 and Apolizumab in Non-Hodgkins Lymphoma Cell Lines. Volume 106, Issue 11, 16 November 2005, Page 4826.

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