1233956-13-2

1233956-13-2 structure
1233956-13-2 structure
  • Name: Volagidemab
  • Chemical Name: Volagidemab
  • CAS Number: 1233956-13-2
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2023-01-18 11:45:27
  • Modify Date: 2025-11-27 15:42:59
  • Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D)[1][2].

Name Volagidemab
Description Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D)[1][2].
Related Catalog
In Vivo Volagidemab (5 mg/kg,皮下注射) 在四氧嘧啶诱导的糖尿病小鼠中抑制 1 型糖尿病表型[2]。 Animal Model: Alloxan-induced diabetic mice [2] Dosage: 5 mg/kg Administration: Subcutaneous injection (s.c.) Result: Reduced phosphorylated CREB protein and PEPCK protein expression to nondiabetic levels.
References

[1]. Pettus J, et al. Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial. Nat Med. 2022 Oct;28(10):2092-2099.  

[2]. Wang MY, et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2503-8.  

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