2415259-90-2

2415259-90-2 structure

2415259-90-2 structure

Name: Ulenistamab
Chemical Name: Ulenistamab
CAS Number: 2415259-90-2
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2023-01-22 10:30:51
Modify Date: 2024-01-13 16:35:59
Ulenistamab (PBP1510) is a first-in-class hunamised IgG1 monoclonal antibody targeting pancreatic adenocarcinoma upregulated factor (PAUF). Ulenistamab can be used for pancreatic cancer (PC) research[1].

Name	Ulenistamab

Description	Ulenistamab (PBP1510) is a first-in-class hunamised IgG1 monoclonal antibody targeting pancreatic adenocarcinoma upregulated factor (PAUF). Ulenistamab can be used for pancreatic cancer (PC) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Ulenistamab (PBP1510) 抑制 PC 细胞系（CFPAC-1 和 BxPC-3）的增殖。同时，PC 细胞系的迁移和侵袭显着减少[1]。
In Vivo	在 6 只猴子的单剂量研究中检查了 Ulenistamab (PBP1510)（高达 20 mg/kg）的药代动力学 (PK) 特征和免疫原性。在猴子研究中，在低剂量和高剂量下观察到全身暴露量按剂量比例增加[1]。
References	[1]. Kedar Diwakar Mandakhalikar, et al. First-in-class monoclonal antibody (mAb) PBP1510 targeting pancreatic adenocarcinoma upregulated factor (PAUF) for pancreatic cancer (PC) treatment: Preclinical perspectives. Journal of Clinical Oncology 2022 40:16_suppl, e16274-e16274.

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