7619-53-6

7619-53-6 structure

Name: Zuclomiphene (citrete)
Chemical Name: Clomiphene citrate, cis
CAS Number: 7619-53-6
Molecular Formula: C₃₂H₃₆ClNO₈
Molecular Weight: 598.08300
Catalog: Research Areas Endocrinology
Create Date: 2018-12-27 19:49:29
Modify Date: 2025-09-10 17:00:30
Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].

Name	Clomiphene citrate, cis
Synonyms	cis-6,cis-11-Methyl-octadecadienoat cis-clomiphene citrate clomphencitrate cis-cis-6,11-Octadecadiensaeuremethylester Methyl-cis,cis-octadeca-6,11-dienoat cis,cis-Octadeca-6,11-diensaeure-methylester clomifen citrate I-Dihydrocitrat zuclomiphene citrate

Description	Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology Research Areas >> Metabolic Disease
Target	Estrogen Receptor/ERR
References	[1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50. [2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6. [3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8. [4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,23,1973