2568358-31-4
2568358-31-4 structure
- Name: Sozinibercept
- Chemical Name: Sozinibercept
- CAS Number: 2568358-31-4
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
- Create Date: 2023-01-24 23:52:02
- Modify Date: 2024-01-02 11:39:07
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Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats[1][2][3].
| Name | Sozinibercept |
|---|
| Description | Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats[1][2][3]. |
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| Related Catalog | |
| Target |
VEGF-C/D[1][2][3] |
| In Vivo | Sozinibercept 抑制激光诱导脉络膜新生血管 (CNV) 模型中 CNV 病变形成和血管渗漏。此外，Sozinibercept 在 CNV 小鼠模型中表现出与 Aflibercept (HY-108801; Eylea®) 相当的疗效[1][2]。 Sozinibercept (玻璃体内注射; 每 4 周一次, 共 4 月) 对 VEGF-C/D 有选择性抑制作用，对链脲佐菌素 (STZ) 诱导大鼠糖尿病视网膜水肿有抑制作用，与 VEGF-A 抑制剂 (Aflibercept) 的抑制作用相当[3]。 |
| References |
| No Any Chemical & Physical Properties |