1847394-95-9
1847394-95-9 structure
- Name: Setrusumab
- Chemical Name: Setrusumab
- CAS Number: 1847394-95-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-15 20:02:45
- Modify Date: 2025-08-25 14:11:05
-
Setrusumab (BPS 804) is a fully humanized monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1].
| Name | Setrusumab |
|---|
| Description | Setrusumab (BPS 804) is a fully humanized monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Setrusumab (100 mg/kg；每周一次，静脉注射，持续 4 周) 抑制小鼠乳腺癌诱导的骨转移和肌肉无力[1]。 Animal Model: 8-week-old female immune-compromised CB-17/lcr-Prkdcscid/Rj mice with MDA-MB-231 breast cancer cells injection[1] Dosage: 100 mg/kg Administration: Intravenous injection; 100 mg/kg once a week for 4 weeks Result: Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65. |
| References |
| No Any Chemical & Physical Properties |