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2750644-31-4

2750644-31-4 structure
2750644-31-4 structure
  • Name: HQ005
  • Chemical Name: HQ005
  • CAS Number: 2750644-31-4
  • Molecular Formula: C15H15N5O2S2
  • Molecular Weight: 361.44
  • Catalog: Research Areas Cancer
  • Create Date: 2023-01-26 18:27:08
  • Modify Date: 2024-04-06 12:09:43
  • HQ005 is a potent CCNK degrader with an DC50 value of 0.041 µM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1].

Name HQ005
Description HQ005 is a potent CCNK degrader with an DC50 value of 0.041 µM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1].
Related Catalog
Target

IC50: 0.041 µM (CCNK)[1]

References

[1]. Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.  

Molecular Formula C15H15N5O2S2
Molecular Weight 361.44
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