2750001-23-9
2750001-23-9 structure
- Name: AZD0095
- Chemical Name: AZD0095
- CAS Number: 2750001-23-9
- Molecular Formula: C27H32N8O2
- Molecular Weight: 500.60
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Monocarboxylate Transporter
- Create Date: 2023-01-14 17:06:35
- Modify Date: 2024-01-02 20:40:45
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AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205)[1].
| Name | AZD0095 |
|---|
| Description | AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib (HY-10205)[1]. |
|---|---|
| Related Catalog | |
| Target |
MCT4:1.3 nM (IC50) |
| In Vitro | AZD0095 (0-50 µM) 抑制 NCI-H358 细胞 (MCT4 高表达) 的增殖，IC50 为 26 nM[1]。 |
| In Vivo | AZD0095 (100 mg/kg, 口服，一天两次) 与 Cediranib (HY-10205) 联合使用抑制小鼠 NCI-H358 异种移植肿瘤的生长[1]。 Animal Model: Murine NCI-H358 xenograft[1] Dosage: 100 mg/kg together with Cediranib (3 mg/kg) Administration: Oral administration (p.o.) Result: Reduced tumor growth more efficiently than AZD0095 or AZD2171 alone. |
| References |
| Molecular Formula | C27H32N8O2 |
|---|---|
| Molecular Weight | 500.60 |