1245634-25-6
1245634-25-6 structure
- Name: Actoxumab
- Chemical Name: Actoxumab
- CAS Number: 1245634-25-6
- Molecular Formula:
- Molecular Weight: 145.9 (kDa)
- Catalog: Research Areas Infection
- Create Date: 2023-01-11 16:18:54
- Modify Date: 2024-01-09 20:54:07
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Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB[1].
| Name | Actoxumab |
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| Description | Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB[1]. |
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| Related Catalog | |
| In Vitro | Actoxumab (10 mg/kg WT or N297Q mutant (N297Q) actoxumab-bezlotoxumab; 2 h plus 24 h) significantly inhibits cell rounding activity in Vero cells under 2 ng/mL TcdA treatment[1]. |
| In Vivo | Actoxumab (0.1-10 mg/kg or 50 mg/kg; i.p.; single dose) shows protective effect in multiple murine models of clostridium difficile infection (CDI), including systemic and local (gut) toxin challenge models, as well as primary and recurrent models of infection in mice[1]. Actoxumab shows a synergy with Bezlotoxumab, and (combination dosage of 3, 30, 300 μg/mouse; i.p.; single dose) prevents both epithelial damage and inflammatory disease[1]. Animal Model: Murine C. difficile infection model in CD1 and C57BL/6 mice (6-8 weeks old)[1] Dosage: Combination dosage of 3, 30, 300 μg/mouse; or ~0.1, 1, and 10 mg/kg Administration: Intraperitoneal injection; single dose; 1 hour before 25 ng TcdA or 25 ng TcdB challenge Result: Protected with Bezlotoxumab, against systemic and intestinal toxin challenge in mice. Animal Model: Ileal loop model in CD1 and C57BL/6 mice (6-8 weeks old)[1] Dosage: 50 mg/kg; or combined with 50 mg/kg Bezlotoxumab Administration: Intraperitoneal injection; single dose Result: Significantly reduced fluid accumulation in toxin-challenged mice (109.4 mg/cm). |
| References |
| Molecular Weight | 145.9 (kDa) |
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