2253937-12-9
2253937-12-9 structure
- Name: Acasunlimab
- Chemical Name: Acasunlimab
- CAS Number: 2253937-12-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
- Create Date: 2023-01-16 11:57:38
- Modify Date: 2025-08-26 09:57:33
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Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer[1][2].
| Name | Acasunlimab |
|---|
| Description | Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer[1][2]. |
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| Related Catalog | |
| In Vitro | Acasunlimab (GEN1046; 0.001-1 μM; 0-525 min) 促进树突状细胞和 T 细胞之间的相互作用并增强 T 细胞活化[1]。 Acasunlimab (0.001-1 μM; 48 h; PD-L1+ Tumor Cells) 在体外诱导剂量依赖性、条件性 T 细胞增殖和细胞因子产生，并增强抗原特异性 T 细胞介导的细胞毒性[1]。 |
| In Vivo | Acasunlimab (5 mg/kg; i.v.; 每周两次，共三个周期) 在双敲入 (dKI) 转基因 C57BL/6 小鼠中具有抗肿瘤活性并抑制肿瘤生长[1]。 Animal Model: Double knock-in (dKI) transgenic C57BL/6 mice[1] Dosage: 5 mg/kg Administration: Intravenous injection; twice weekly for three cycles Result: Had antitumor activity in double knock-in (dKI) transgenic C57BL/6 mice. |
| References |
| No Any Chemical & Physical Properties |