2819989-75-6
2819989-75-6 structure
- Name: PBRM1-BD2-IN-8
- Chemical Name: PBRM1-BD2-IN-8
- CAS Number: 2819989-75-6
- Molecular Formula: C15H13BrN2O
- Molecular Weight: 317.18
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-11-27 07:02:20
- Modify Date: 2025-08-23 01:25:35
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PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity[1].
| Name | PBRM1-BD2-IN-8 |
|---|
| Description | PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
IC50: 0.16 μM (PBRM1-BD2)[1] |
| In Vitro | PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells[1]. Cell Viability Assay[1] Cell Line: LNCaP cells Concentration: 0-100 μM Incubation Time: 48 hours Result: Inhibited the growth of LNCaP cells with IC50 value of about 9 μM. |
| Molecular Formula | C15H13BrN2O |
|---|---|
| Molecular Weight | 317.18 |