304685-40-3

304685-40-3 structure

Name: BRD4-IN-4
Chemical Name: WAY-383515
CAS Number: 304685-40-3
Molecular Formula: C₁₇H₁₈N₂O₃S
Molecular Weight: 330.40
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-12-04 08:10:27
Modify Date: 2024-04-12 17:50:53
BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].

Name	WAY-383515
Synonyms	1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one 1-Ethyl-6-(1-pyrrolidinylsulfonyl)benzo[cd]indol-2(1H)-one 1-Ethyl-6-(pyrrolidine-1-sulfonyl)-1H-benzo[cd]indol-2-one Benz[cd]indol-2(1H)-one, 1-ethyl-6-(1-pyrrolidinylsulfonyl)-

Description	BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 6.83 μM (BRD4)[1]
References	[1]. Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273.