1831169-11-9
1831169-11-9 structure
- Name: UBA5-IN-1
- Chemical Name: UBA5-IN-1
- CAS Number: 1831169-11-9
- Molecular Formula: C26H40F6N10O11S2Zn
- Molecular Weight: 912.16
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2022-11-07 06:55:00
- Modify Date: 2024-01-31 13:09:19
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UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5[1].
| Name | UBA5-IN-1 |
|---|
| Description | UBA5-IN-1 (compound 8.5) is a selective UBA5 inhibitor with an IC50 value of 4.0 μM. UBA5-IN-1 inhibits cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5[1]. |
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| Related Catalog | |
| Target |
IC50: 4.0 μM (UBA5), 78.5 μM (UAE), 66.8 μM (NAE)[1] |
| In Vitro | UBA5-IN-1 (0.1-1000 μM) shows dose-dependent inhibition effect to UBA5 with an IC50 value of 4.0 μM, and inhibits UAE and NAE with IC50 values of 78.5 and 66.8 μM, respectively[1]. UBA5-IN-1 (0-5 μM) inhibits UBA5 non-competitively with respect to ATP[1]. UBA5-IN-1 (10 μM) shows no effect on ATP binding to human kinase[1]. UBA5-IN-1 (0-50 μM; 72 h) effects cell proliferation of Sk-Luci6 cancer cells with high expression levels of UBA5[1]. Cell Proliferation Assay[1] Cell Line: Sk-Luci6 cancer cells with high expression levels of UBA5 Concentration: 0-50 μM Incubation Time: 0-72 h Result: Showed selective anti-proliferative activity for Sk-Luci6 cancer cells which expressed higher UBA5 protein levels, but showed no anti-proliferative activity to MRC9 lung fibroblasts and A549 carcinoma cells. |
| References |
| Molecular Formula | C26H40F6N10O11S2Zn |
|---|---|
| Molecular Weight | 912.16 |