1036734-93-6
1036734-93-6 structure
- Name: Teprotumumab
- Chemical Name: Teprotumumab
- CAS Number: 1036734-93-6
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways GPCR/G Protein TSH Receptor
- Create Date: 2022-11-11 09:12:05
- Modify Date: 2023-01-15 12:50:46
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Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].
| Name | Teprotumumab |
|---|
| Description | Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1]. |
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| Related Catalog | |
| In Vitro | Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours[1]. |
| No Any Chemical & Physical Properties |