2311863-36-0
2311863-36-0 structure
- Name: TRPC6-IN-3
- Chemical Name: TRPC6-IN-3
- CAS Number: 2311863-36-0
- Molecular Formula: C22H22FN5O3
- Molecular Weight: 423.44
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2022-10-11 12:04:46
- Modify Date: 2024-04-09 20:31:51
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TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system[1].
| Name | TRPC6-IN-3 |
|---|
| Description | TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system[1]. |
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| Related Catalog | |
| In Vivo | TRPC6-IN-3 (compound 17; 1-10 mg/kg; p.o.; orally 12 h and 2 h before LPS challenge; LPS-induced mice) inhibits LPS-induced vascular leakage and inhibits accumulation of Broncho-Alveolar-Lavage protein (BALF protein) in a mouse model[1]. TRPC6-IN-3 (3 mg/kg; p.o.; daily, for 4 d; H1N1-induced mice) reduces H1N1-induced vascular leakage in a mouse model[1]. Animal Model: LPS-induced mice[1] Dosage: 1, 3, and 10 mg/kg Administration: Oral administration; orally 12 h and 2 h before LPS challenge Result: Reduced BALF protein concentration of 56 % at 3 mg/kg and 62 % at 10 mg/kg. Animal Model: H1N1-induced mice[1] Dosage: 3 mg/kg Administration: Oral administration; daily, for 4 days Result: Inhibited Evans blue extravasation from the blood to the BALF and reduced BALF Evans blue by 24 % at 3 mg/kg. |
| References |
[1]. Thierry B, et, al. Inhibitors of TRPC6 for treating respiratory conditions. WO2021209510. |
| Molecular Formula | C22H22FN5O3 |
|---|---|
| Molecular Weight | 423.44 |