1637532-83-2
1637532-83-2 structure
- Name: PM-81I
- Chemical Name: PM-81I
- CAS Number: 1637532-83-2
- Molecular Formula: C43H58F2N3O10P
- Molecular Weight: 845.91
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2022-10-12 06:50:15
- Modify Date: 2024-04-02 18:06:20
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PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1].
| Name | PM-81I |
|---|
| Description | PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
STAT6[1]. |
| In Vitro | PM-81I (0.05, 0.1, 0.5, 1, 2.5, 5 µM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Bease-2B immortalized human epithelial airway cells[1]. Western Blot Analysis[1] Cell Line: Bease-2B immortalized human epithelial airway cells Concentration: 0.05, 0.1, 0.5, 1, 2.5, 5 µM Incubation Time: 2 h Result: Decreased phosphorylation levels of STAT6 to18%, 13%, 13% when at 1, 2.5 and 5 µM, respectively. |
| References |
[1]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2. |
| Molecular Formula | C43H58F2N3O10P |
|---|---|
| Molecular Weight | 845.91 |