2574390-27-3
2574390-27-3 structure
- Name: MM3122
- Chemical Name: MM3122
- CAS Number: 2574390-27-3
- Molecular Formula: C31H39N9O6S
- Molecular Weight: 665.76
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2022-10-09 10:15:25
- Modify Date: 2024-04-08 17:28:55
-
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells[1].
| Name | MM3122 |
|---|
| Description | MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively[1]. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, VSV-SARS CoV-2 chimera calu-3 and MERS VSV pseudotype calu-3 with the EC50 values of 74, 0.43 and 0.87 nM, respectively[1]. |
| In Vivo | MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice[1]. MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice[1]. |
| References |
| Molecular Formula | C31H39N9O6S |
|---|---|
| Molecular Weight | 665.76 |