1229575-09-0
1229575-09-0 structure
- Name: Lenzilumab
- Chemical Name: Lenzilumab
- CAS Number: 1229575-09-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2022-10-23 14:14:17
- Modify Date: 2025-08-26 17:27:12
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Lenzilumab (KB 003) is a humanized monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies[1][2].
| Name | Lenzilumab |
|---|
| Description | Lenzilumab (KB 003) is a humanized monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies[1][2]. |
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| Related Catalog | |
| In Vivo | Lenzilumab (i.p., 10 mg/kg, daily, 10 days) inhibits GM-CSF without inhibiting the cellular function of CAR-T and enhances its antitumor activity in NSG mice[1]. Animal Model: NSG mice with CART19 cells[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; daily; 10 days Result: Neutralized GM-CSF, had antitumor activity and improved the proliferation of cytokine release syndrome (CRS) and neuroinflammation (NI). |
| References |
| No Any Chemical & Physical Properties |