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1544300-84-6

1544300-84-6 structure
1544300-84-6 structure
  • Name: Dasiglucagon
  • Chemical Name: Dasiglucagon
  • CAS Number: 1544300-84-6
  • Molecular Formula: C152H222N38O50
  • Molecular Weight: 3381.62
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2022-10-21 05:19:17
  • Modify Date: 2024-04-02 21:59:26
  • Dasiglucagon is a novel human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research[1][2][3].

Name Dasiglucagon
Description Dasiglucagon is a novel human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research[1][2][3].
Related Catalog
In Vivo 1.19Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels[2]. Dasiglucagon dose 0.1 mg 0.3 mg 0.6 mg 1.0 mg N 5 16 16 16 AUC0–30min (pmol*h/L) 99.4 (32.0) 302 (78.9) 444 (163) 884 (307) AUC0–360min (pmol*h/L) 451 (123) 1360 (166) 1630 (368) 4800 (697) AUC0–inf (pmol*h/L) 451 (123) 1360 (166) 2640 (365) 4810 (696) Cmax (pmol/L) 334 (113) 976 (208) 1570 (445) 2800 (767) tmax (h) 0.50 (0.5-0.6) 0.63 (0.3-0.8) 0.58 (0.5-1.7) 0.63 (0.3-0.8) t1/2 (h) 0.43 (0.07) 0.43 (0.07) 0.49 (0.14) 0.54 (0.17)
References

[1]. Bo Xu, et al. Dasiglucagon: an effective medicine for severe hypoglycemia. Eur J Clin Pharmacol. 2021 Dec;77(12):1783-1790.

[2]. Ulrike Hövelmann, et al. Pharmacokinetic and Pharmacodynamic Characteristics of Dasiglucagon, a Novel Soluble and Stable Glucagon Analog. Diabetes Care. 2018 Mar;41(3):531-537.

[3]. Yongjing Ju, et al. Dasiglucagon for treating severe hypoglycemia in patients with diabetes. Expert Rev Clin Pharmacol. 2022 Jul;15(7):799-803.

Molecular Formula C152H222N38O50
Molecular Weight 3381.62
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