947687-12-9
947687-12-9 structure
- Name: Cixutumumab
- Chemical Name: Cixutumumab
- CAS Number: 947687-12-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2022-10-21 05:07:32
- Modify Date: 2025-08-26 20:38:43
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Cixutumumab (IMC-A12) is a humanized anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer[1].
| Name | Cixutumumab |
|---|
| Description | Cixutumumab (IMC-A12) is a humanized anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer[1]. |
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| Related Catalog | |
| Target |
IGF-1R[1]. |
| In Vitro | Cixutumumab (IMC-A12) (0.01-100 nM; 96 h) exhibits at least 50% growth inhibition in CHLA-9, TC-71and Rh41 cells[1]. Cell Viability Assay[1] Cell Line: CHLA-9, TC-71, Rh41 cells Concentration: 0.01-100 nM Incubation Time: 96 h Result: Inhibited CHLA-9, TC-71and Rh41 cells growth with IC50 values of 49.31, 0.66 and 0.04 nM, respectively. |
| In Vivo | Cixutumumab (IMC-A12) (1 mg/rat; i.p.; twice weekly for 6 weeks) shows broad-spectrum antitumor activity, inhibits tumor growth of the PPTP’s in vivo solid tumor panels[1]. Animal Model: CB17SC-M scid-/- female mice (solid tumor xenografts model)[1]. Dosage: 1 mg/rat Administration: Intraperitoneal injection; twice weekly for 6 weeks. Result: Demonstrated broad antitumor activity against the PPTP’s in vivo solid tumor panels, with the activity primarily being tumor growth inhibition rather than tumor regression. |
| References |
| No Any Chemical & Physical Properties |