1425485-87-5
1425485-87-5 structure
- Name: B-Raf IN 10
- Chemical Name: B-Raf IN 10
- CAS Number: 1425485-87-5
- Molecular Formula: C22H21F3N4O4S
- Molecular Weight: 494.49
- Catalog: Signaling Pathways MAPK/ERK Pathway Raf
- Create Date: 2022-10-15 07:17:53
- Modify Date: 2024-04-09 09:54:24
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B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1].
| Name | B-Raf IN 10 |
|---|
| Description | B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity[1]. |
|---|---|
| Related Catalog | |
| Target |
BRAF-V600E:< 50 nM (IC50) Braf:50-100 nM (IC50) |
| In Vitro | B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E[1]. B-Raf IN 10 shows an IC50 between 50 and 100 nM against BRAF, less than 50 nM against BRAF V600E[1]. B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cells growth but not CHL-1 and SK-MEL-31 cells[1]. Cell Viability Assay[1] Cell Line: A375, SK-MEL-28, SK-MEL-31 and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC50s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. |
| References |
| Molecular Formula | C22H21F3N4O4S |
|---|---|
| Molecular Weight | 494.49 |