2768139-73-5
2768139-73-5 structure
- Name: (Rac)-ErSO-DFP
- Chemical Name: (Rac)-ErSO-DFP
- CAS Number: 2768139-73-5
- Molecular Formula: C20H17F5N2O2
- Molecular Weight: 412.35
- Catalog: Research Areas Cancer
- Create Date: 2022-08-31 12:05:37
- Modify Date: 2024-03-24 11:16:37
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(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1)[1].
| Name | (Rac)-ErSO-DFP |
|---|
| Description | (Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1)[1]. |
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| Related Catalog | |
| Target |
IC50: 35 nM (MCF-7 cells)[1]. |
| In Vitro | (Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 0.001-1 µM Incubation Time: 24 h Result: Showed a sustained activity of anticancer with IC50 of 35 nM. |
| In Vivo | (Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses[1]. Animal Model: Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)[1]. Dosage: 5 mg/kg Administration: Intravenous injection; once-a-week for 3 total doses. Result: Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer. |
| References |
[1]. Hergenrother, et al. Enzyme-activating compounds and compositions. Patent WO2022087234A1. |
| Molecular Formula | C20H17F5N2O2 |
|---|---|
| Molecular Weight | 412.35 |