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207623-15-2

207623-15-2 structure

207623-15-2 structure

Name: ODN 1982
Chemical Name: ODN 1982
CAS Number: 207623-15-2
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Inflammation/Immunology
Create Date: 2022-09-04 09:21:43
Modify Date: 2024-04-09 11:02:57
ODN 1982 is a unmethylated CpG oligodeoxyribonucleotide (ODN), can be used to prepare DNA vaccines. ODN 1982 inhibits R-848 signaling. ODN 1982 sequence: 5’-tccaggacttctctcaggtt-3’[1][2].

Name	ODN 1982

Description	ODN 1982 is a unmethylated CpG oligodeoxyribonucleotide (ODN), can be used to prepare DNA vaccines. ODN 1982 inhibits R-848 signaling. ODN 1982 sequence: 5’-tccaggacttctctcaggtt-3’[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	ODN 1982 (0.1, 1 and 5 μM) has no influence on NF-κB induction in hTLR7-expressing HEK293 cells[2]. ODN 1982 (0.1-10 μM; 24 h) together with Loxoribine does not induce IL-12p40 above the medium background, and yields few TNF+ monocytes[2].
References	[1]. Tudor D, et al. TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines. Vaccine. 2005 Jan 26;23(10):1258-64. [2]. Jurk M, et al. Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Eur J Immunol. 2006 Jul;36(7):1815-26.

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