241127-79-7

241127-79-7 structure

Name: NSC689857
Chemical Name: NSC689857
CAS Number: 241127-79-7
Molecular Formula: C₂₅H₂₉NO₄
Molecular Weight: 407.50
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-09-01 09:11:55
Modify Date: 2024-04-14 00:35:00
NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2].

Name	NSC689857

Description	NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	IC50: 36 μM (Skp2-Cks1), 30 μM (p27 ubiquitylation)[1]
References	[1]. Vuong W, et al. High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov;359(2):256-261. [2]. Lough L, et al. Chemical probes of Skp2-mediated p27 ubiquitylation and degradation. Medchemcomm. 2018 Jun 11;9(7):1093-1104.

Molecular Formula	C₂₅H₂₉NO₄
Molecular Weight	407.50