| In Vitro |
Misetionamide (OTD) (0-2000 μM; 0-72 h) induces cell death in TNBC cells[2]. Misetionamide (OTD) (0-2000 μM; 12 h) inhibits TNBC cells proliferation[2]. Misetionamide (OTD) (0-1000 μM; 18 h) induces necrosis and apoptosis in TNBC cells[2]. Misetionamide (OTD) (250-1000 μM; 18 h) induces cell death by a ROS-dependent mechanism in TNBC cells[2]. Cell Viability Assay[2] Cell Line: TNBC cells Concentration: 0, 100, 200, 500, 1000 and 2000 μM Incubation Time: 0, 24, 48 and 72 hours Result: Induced cell death in TNBC cells dose- and time-dependently. Cell Proliferation Assay[2] Cell Line: TNBC cells Concentration: 0, 100, 200, 500, 1000 and 2000 μM Incubation Time: 12 hours Result: Inhibited TNBC cell proliferation dose-dependently. Cell Viability Assay[2] Cell Line: TNBC cells Concentration: 250, 500, 750, 1000 μM Incubation Time: 24 hours Result: Induced TNBC cell death mainly dependent on ROS generation. Apoptosis Analysis[2] Cell Line: TNBC cells Concentration: 0, 100, 250, 750, 1000 μM Incubation Time: 18 hours Result: Induced necrosis and apoptosis in TNBC cells dose-dependently and induced cell apoptosis is a underlying mechanism to kill f TNBC cells.
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