2102021-49-6

2102021-49-6 structure

2102021-49-6 structure

Name: MDTF free acid
Chemical Name: MDTF free acid
CAS Number: 2102021-49-6
Molecular Formula: C₁₆H₁₁F₄NO₉S
Molecular Weight: 469.32
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2022-10-15 13:27:04
Modify Date: 2024-04-03 11:35:59
MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	MDTF free acid

Description	MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
In Vitro	MDTF free acid (50 μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe[1].
References	[1]. Dovgan I, et, al. 2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep. 2016 Aug 9;6:30835.

Molecular Formula	C₁₆H₁₁F₄NO₉S
Molecular Weight	469.32