1467052-84-1
1467052-84-1 structure
- Name: Tazemetostat hydrochloride
- Chemical Name: Tazemetostat hydrochloride
- CAS Number: 1467052-84-1
- Molecular Formula: C34H45ClN4O4
- Molecular Weight: 609.20
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2022-08-17 06:48:28
- Modify Date: 2024-01-03 15:34:07
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Tazemetostat (EPZ-6438) hydrochloride is a potent, selective and orally active EZH2 inhibitor with IC50 values of 11 and 16 nM for EZH2 peptide and nucleosome, respectively. Tazemetostat hydrochloride can be used for cancer research[1].
| Name | Tazemetostat hydrochloride |
|---|
| Description | Tazemetostat (EPZ-6438) hydrochloride is a potent, selective and orally active EZH2 inhibitor with IC50 values of 11 and 16 nM for EZH2 peptide and nucleosome, respectively. Tazemetostat hydrochloride can be used for cancer research[1]. |
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| Related Catalog | |
| In Vitro | Tazemetostat (EPZ-6438; 0.49-7.6 μM, 11 days) hydrochloride inhibits multi wild-type and mutant lymphoma cell lines proliferation with IC50s of 0.49-7.6 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: Wild-type and mutant lymphoma cell lines Concentration: 0.49-7.6 μM Incubation Time: 11 days Result: Inhibited DOHH-2 cell (EZH2 wild-type; IC50=1.7 μM), Farage cell (EZH2 wild-type; IC50=99 nM), OCI-LY19 cell (EZH2 wild-type; IC50=6.2 μM), Toledo cell (EZH2 wild-type; IC50=7.6 μM), KARPAS-422 (EZH2 Y646N; IC50=1.8 nM), Pfeiffer (EZH2 A682G; IC50=0.49 nM), RL cell line (EZH2 Y646N; IC50=5.8 μM), SU-DHL-10 (EZH2 Y646F; IC50=5.8 nM), SU-DHL-6 (EZH2 Y646N; IC50=4.7 nM), WSU-DLCL2 (EZH2 Y646F; IC50=8.6 nM) proliferation. |
| In Vivo | Tazemetostat (EPZ-6438; 250-500 mg/kg; p.o.; twice daily; for 21-28 days) hydrochloride practically eliminates the fast-growing G401 tumors[1]. Animal Model: SCID mice bearing s.c. G401 xenografts[1] Dosage: 125 mg/kg, 250 mg/kg and 500 mg/kg Administration: Oral administration; twice daily; 28 days Result: Eliminated the fast-growing G401 tumors. |
| References |
| Molecular Formula | C34H45ClN4O4 |
|---|---|
| Molecular Weight | 609.20 |