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2653337-73-4

2653337-73-4 structure

2653337-73-4 structure

Name: STING agonist-9
Chemical Name: STING agonist-9
CAS Number: 2653337-73-4
Molecular Formula: C₃₉H₄₇N₁₃O₆S
Molecular Weight: 825.94
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2022-08-11 10:37:54
Modify Date: 2025-08-25 16:48:32
STING agonist-9 (Compound 45) is a potent STING agonist with an EC50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity[1].

Name	STING agonist-9

Description	STING agonist-9 (Compound 45) is a potent STING agonist with an EC50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
Target	EC50: 1.2 nM (h-STING), 32.82 μM (m-STING)[1]
In Vitro	STING agonist-9 (Compound 45) directly binds to various h-STING isoforms and m-STING[1]. STING agonist-9 potently activates both ISG and NF-κB signaling pathways[1].
In Vivo	STING agonist-9 (Compound 45) significantly inhibits the tumor growth in allograft 4T1 and CT26 tumor models by systemic administration, and induces tumor regression in CT26 tumor model without inducing weight loss[1].
References	[1]. Niu J, et al. Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration. Eur J Med Chem. 2022 Aug 5;238:114482.

Molecular Formula	C₃₉H₄₇N₁₃O₆S
Molecular Weight	825.94

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