56173-05-8

56173-05-8 structure

56173-05-8 structure

Name: PCAF-IN-2
Chemical Name: PCAF-IN-2
CAS Number: 56173-05-8
Molecular Formula: C₁₀H₇F₃N₆
Molecular Weight: 268.20
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-26 20:29:38
Modify Date: 2024-01-02 20:31:42
PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1].

Name	PCAF-IN-2

Description	PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	PCAF:5.31 μM (IC50)
In Vitro	PCAF-IN-2 shows anti-tumour activity with IC50s of 3.06, 5.69, 7.56, 2.83 µM for HePG2, MCF-7, PC3, HCT-116 cells, respectively[1]. PCAF-IN-2 (10 µM; 24 h) induces apoptosis and arrest the cell cycle at the G2/M phase in HePG2 cells[1].
References	[1]. Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.

Molecular Formula	C₁₀H₇F₃N₆
Molecular Weight	268.20