2243136-03-8

2243136-03-8 structure

Name: JAK3/BTK-IN-6
Chemical Name: JAK3/BTK-IN-6
CAS Number: 2243136-03-8
Molecular Formula: C₂₁H₁₇BF₃N₅O₃
Molecular Weight: 455.20
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-08-12 12:10:33
Modify Date: 2024-04-06 16:11:43
JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1].

Name	JAK3/BTK-IN-6

Description	JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Target	JAK3:0.4 nM (IC50) JAK2:657.9 nM (IC50) JAK1:>1000 nM (IC50) Tyk2:>1000 nM (IC50)
In Vitro	JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively[1].
References	[1]. Ren J, et al. Design and synthesis of boron-containing diphenylpyrimidines as potent BTK and JAK3 dual inhibitors. Bioorg Med Chem. 2020 Jan 15;28(2):115236.

Molecular Formula	C₂₁H₁₇BF₃N₅O₃
Molecular Weight	455.20