2481484-51-7

2481484-51-7 structure

Name: COX-2/5-LOX-IN-3
Chemical Name: COX-2/5-LOX-IN-3
CAS Number: 2481484-51-7
Molecular Formula: C₁₇H₁₆ClN₃O₂S
Molecular Weight: 361.85
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-12 11:47:56
Modify Date: 2024-04-09 17:47:32
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].

Name	COX-2/5-LOX-IN-3

Description	COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	COX-2:5.45 μM (IC50) COX-1:45.73 μM (IC50) 5-LOX:4.33 μM (IC50)
In Vivo	COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo[1]. Animal Model: Male Sprague Dawley rats[1] Dosage: 2.622 X 10-5 mol/kg Administration: Oral administration Result: The percentage inhibition of edema (%I) reached 58.77% after 4h.
References	[1]. Qandeel NA, et al. Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives. Bioorg Chem. 2020 Sep;102:103890.

Molecular Formula	C₁₇H₁₆ClN₃O₂S
Molecular Weight	361.85