2586195-28-8

2586195-28-8 structure

Name: Androgen receptor antagonist 5
Chemical Name: Androgen receptor antagonist 5
CAS Number: 2586195-28-8
Molecular Formula: C₂₁H₁₅F₄N₅O₃S
Molecular Weight: 493.43
Catalog: Research Areas Cancer
Create Date: 2022-08-15 17:01:56
Modify Date: 2025-08-27 16:31:49
Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].

Name	Androgen receptor antagonist 5

Description	Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
Target	IC50: 6.17 μM (AR)[1]
In Vitro	Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1].
References	[1]. Xu X, et al. Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists. Eur J Med Chem. 2020;192:112196.

Molecular Formula	C₂₁H₁₅F₄N₅O₃S
Molecular Weight	493.43