1580-42-3

1580-42-3 structure

Name: SARS-CoV-2-IN-15
Chemical Name: SARS-CoV-2-IN-15
CAS Number: 1580-42-3
Molecular Formula: C₁₄H₉ClF₃NO₂
Molecular Weight: 315.67
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2022-07-11 22:41:58
Modify Date: 2024-04-06 21:31:16
SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Name	SARS-CoV-2-IN-15

Description	SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
References	[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Molecular Formula	C₁₄H₉ClF₃NO₂
Molecular Weight	315.67