1639040-95-1

1639040-95-1 structure

Name: pan-HER-IN-2
Chemical Name: pan-HER-IN-2
CAS Number: 1639040-95-1
Molecular Formula: C₁₉H₁₅BrClN₅O
Molecular Weight: 444.71
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-02 00:24:01
Modify Date: 2024-01-06 19:15:36
pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HER inhibitor with IC50 values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities[1].

Name	pan-HER-IN-2

Description	pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HER inhibitor with IC50 values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.72 nM (IC50) EGFR (L858R/T790M):8.2 nM (IC50) HER2:75.1 nM (IC50) HER4:2.0 nM (IC50)
References	[1]. Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249.

Molecular Formula	C₁₉H₁₅BrClN₅O
Molecular Weight	444.71