1639040-94-0

1639040-94-0 structure

Name: pan-HER-IN-1
Chemical Name: pan-HER-IN-1
CAS Number: 1639040-94-0
Molecular Formula: C₁₉H₁₄BrN₅O
Molecular Weight: 408.25
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-01 19:14:02
Modify Date: 2024-01-09 15:35:33
pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].

Name	pan-HER-IN-1

Description	pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.38 nM (IC50) HER4:1.6 nM (IC50) EGFRL858R/T790M/C797S:2.2 nM (IC50) HER2:3.5 nM (IC50)
References	[1]. Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249.

Molecular Formula	C₁₉H₁₄BrN₅O
Molecular Weight	408.25