2453183-75-8

2453183-75-8 structure

2453183-75-8 structure

Name: Nampt-IN-8
Chemical Name: Nampt-IN-8
CAS Number: 2453183-75-8
Molecular Formula: C₃₆H₃₅N₃O₄
Molecular Weight: 573.68
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-26 09:49:06
Modify Date: 2024-01-09 14:36:28
Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].

Name	Nampt-IN-8

Description	Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt
Target	IC50: 0.183 μM (NAMPT)[1]
In Vitro	Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM[1].
In Vivo	Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity[1].
References	[1]. Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65(11):7746-7769.

Molecular Formula	C₃₆H₃₅N₃O₄
Molecular Weight	573.68