2477726-83-1

2477726-83-1 structure

Name: EGFR-IN-56
Chemical Name: EGFR-IN-56
CAS Number: 2477726-83-1
Molecular Formula: C₂₃H₂₂N₄O₃S
Molecular Weight: 434.51
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-03 19:53:24
Modify Date: 2024-01-09 18:04:17
EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

Name	EGFR-IN-56

Description	EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRT790M:541.7 nM (IC50) EGFRL858R/T790M:132.1 nM (IC50)
References	[1]. Xiao Z, et al. Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115669.

Molecular Formula	C₂₃H₂₂N₄O₃S
Molecular Weight	434.51