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1610894-92-2

1610894-92-2 structure

1610894-92-2 structure

Name: COX-2-IN-16
Chemical Name: COX-2-IN-16
CAS Number: 1610894-92-2
Molecular Formula: C₁₉H₁₂BrN₃O₂
Molecular Weight: 394.22
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-07-01 14:21:07
Modify Date: 2024-01-10 07:21:28
COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity[1].

Name	COX-2-IN-16

Description	COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:102 μM (IC50)
In Vivo	COX-2-IN-16 (compound 2b) (100 mg/kg; p.o.) shows better reduction in the edema formation by 42% in a rat paw edema model[1].
References	[1]. García-Aranda MI, et al. Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore. Bioorg Med Chem. 2020 May 1;28(9):115427.

Molecular Formula	C₁₉H₁₂BrN₃O₂
Molecular Weight	394.22

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